Journal of Food and Drug Analysis

About the journal

The Journal of Food and Drug Analysis (JFDA) is the official peer-reviewed publication of the Food and Drug Administration, Taiwan (TFDA). The JFDA is an international journal that is dedicated to publishing original research and review papers on the analyses of food, drugs, medical devices, cosmetics ...

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Editor-in-Chief & editorial board

Publishing timeline

7 days： Submission to first decision　　　　 35 days：Submission to decision after review　　　　　　　　　　　　

　　　　

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Current Issue

Volume 34, Issue 4 (2026)View issue

Special Issue Articles

Current Articles

  • Review ArticlesNanoparticle-Based Innovations in Lung Cancer Treatment: Challenges and Opportunities
    20 October 2026Shailesh Sharma, Chamanpreet Kaur, Gurminder Kaur, Surajpal Verma
    Nanoparticles (NPs) present a therapeutic revolution in the context of lung cancer, having several and unique advantages over many traditional drugs, such as increased specificity, minimal side effects on healthy tissues, and increased efficacy. It definitely provides a detailed understanding of preparation techniques for nanoparticles for lung cancer treatment, as well as assessment approaches and therapeutic applications of nanoparticles in cancer treatment. The incorporation of drugs into nanoparticle-based systems is then critically discussed with emphasis on their capability to circumvent MDR and target tumour cell lines. Also, the review mentioned the development in the agnostic application, the nanoparticles that are used both for diagnostics and therapeutic procedures in order to develop a personalized medicine. However, several problems pertaining to translation in the nano-medicine area are exceptional, such as scalability, stability, and regulatory issues. To effectively overcome these barriers, it is crucial to continue interdisciplinary work in order to realize nanoparticles full clinical potential. The conversation turns to advances, how nanoparticles may be combined with novel technologies like gene editing and Artificial Intelligence to design a new approach to lung cancer treatment. It is developed to help researchers and clinicians endeavouring to advance in the section of nanoparticle-based lung cancer therapies by summing up the existing developments and discussing further ideas.

Most Popular Articles

  • Review Articles
    14 July 2020

    Chemical derivatization for the analysis of drugs by GC-MS - A conceptual review

    D.-L. Lin, S.-M. Wang, C.-H. Wu, B.-G. Chen, R.H. Liu
    Drugs are often chemically derivatized prior to their GC-MS analysis for the following reasons: (a) to bring the analytes to the chemical forms that are more compatible to the chromatographic environment; (b) to create a separation mechanism or to maximize resolution efficiency; (c) to improve detection or structural elucidation effectiveness; or (d) to make use of the analytes' specific structural features for analyticl needs. Analytes that are strongly acidic, basic or with functional groups, that may not vaporize or may interact with (irreversibly or reversibly) silanol groups or contaminating compounds present in the chromatographic system, can be more effectively analyzed after chemical derivatization. Enantiomers can be chromatographically resolved by achiral columns after being converted into diastereomers using chiral reagents; derivatization may also bring the retention time of the targeted analytes to a more desirable range. Introduction of certain elements or groups through chemical derivatization may enhance the detector's response or generate mass spectra helpful to the elucidation of the analytes' structural features. In conclusion, commonly used derivatization reagents for silylation, acylation, and alkylation are summarized along with comments on some practical considerations.
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  • Original Articles
    14 July 2020

    A rapid method for determination of ethanol in alcoholic beverages using capillary gas chromatography

    M.-L. Wang, Y.-M. Choong, N.-W. Su, M.-S. Lee
    A simple and rapid method was developed to determine ethanol content in alcoholic beverages using megapore polar column (CP-Wax 58 CB, 30 m × 0.53 mm) with direct injection gas chromatography. Contrary to packed GLC method, distillation and/or stepwise dilution of samples were not necessary by the method developed in this study. Ethanol in sample was injected directly into GC for analysis, after adding suitable amount of internal standard, acetonitrile solution. Using this method, less than 8 min was required to obtain result since sample preparation, and the limit of quantitation (LOQ) was about 0.5 μg/mL. Recovery studies were performed using 0.5 mL of red wine and whisky. Each was spiked with ethanol at 50 and 100 mg, respectively. The recoveries were found in the range of 99-104% and 99-101%, respectively. The coefficients of variation were less than 3.4%. Comparisons of the AOAC method (AOAC 969.12 and 920.57) with current method showed no significant difference. These results suggested that precision of direct injection GC method was higher than that of AOAC methods. Several commercial alcohol beverages, including distilled and non-distilled spirits, were analyzed by the current method. The ethanol content of distilled and non-distilled spirit were found as: 165.2 ± 4.9-415.7 ± 17.6 and 28.2 ± 0.8-141.2 ± 4.9 mg/mL, respectively. Using this GC method, we could change the concentration in gravimetric percentage (%, w/v) to volumetric percentage (%, v/v) by the equation (%, w/v) = 0.814 (%, v/v) with linear coefficient R2, higher than 0.999.
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  • Original Articles
    10 March 2023

    Chemical transformation of cannabidiol into psychotropic cannabinoids under acidic reaction conditions: Identification of transformed products by GC-MS

    Minsun Jeong, Sangin Lee, Chaeyoung Seo, Eunjeong Kwon, Soohyang Rho, Mansoo Cho, Moon Yeon Kim, Wonwoong Lee, Yong Sup Lee, Jongki Hong
    Recently, cannabidiol (CBD), one of the major components of the Cannabis species, has been a focus in the cannabis industry due to its various pharmacological effects. Interestingly, CBD can be converted into several psychoactive cannabinoids, such as 9-tetrahydrocannabinol (Δ9-THC) and its structural isomers, under acidic reaction conditions. In this study, chemical transformation of CBD in ethanol solution was conducted with variation in pH at 2.0, 3.5, and 5.0 by addition of 0.1 M hydrochloric acid (HCl). These resulting solutions were derivatized with trimethylsilyl (TMS) reagent and analyzed using GC/MS-scan mode. Time profiles of CBD degradation and transformation of products were examined according to variations in pH and temperature. Several transformed products produced after the acidic reaction of CBD were identified by matching retention times and mass spectra to authentic standards. Regarding the identification of products without authentic standards, the EI-mass spectra of such cannabinoid-OTMS derivatives were interpreted according to structural class, suggesting mass fragmentation pathways. From the GC/MS data, Δ9-THC, CBC, and ethoxy-hexahydrocannabinol (HHC) analogues were shown to be major components, and THC isomers (Δ8- and Δ10-THCs) and 9-hydroxy-HHC were observed as minor components. Using time profile data, the acidity of the reaction solution was an important factor in degradation of CBD. Degradation of CBD and formation of THC rarely occurred at pH 5.0, even at 70 ℃ with a long process time of 24 h. In contrast, degradation of CBD occurred readily at pH 3.5 and 30 ℃ over a short process time and was further accelerated by lowering pH, increasing temperature, and lengthening the process time. Based on profile data and identified transformed products, formation pathways from the degradation of CBD under acidic reaction conditions are suggested. Among the transformed products, seven components are known to have psychoactive effects. Thus, industrial CBD manufacturing processes in food and cosmetic products should be carefully controlled. These results will provide important guidelines on the control of manufacturing processes, storage, fermentation processes, and new regulation in industrial applications of CBD.
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  • Review Articles
    14 July 2020

    HPTLC method development and validation: Strategy to minimize methodological failures

    P. Rashmin, P. Mrunali, D. Nitin, D. Nidhi, P. Bharat
    This paper provides information regarding HPTLC-based analytical method development and evaluation of validation characteristics in accordance with best practice. As a result it meets standards comparable with other chromatographic techniques with specific aim to minimize confusion and methodological failure. The poor performance to the method development may be caused by systematic and scientific approach for the selection of separation mode, stationary phase and mobile phase not taken into consideration. The poor validation practice may be caused by validation guidelines which are not fully understood or partially neglected, steps of the analytical procedure are not fully considered during validation or specification limits defining validation characteristics are not described.
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  • Original Articles
    15 June 2020

    A multi-analyte LC-MS/MS method for screening and quantification of nitrosamines in sartans

    Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang
    An incident of sartan medicine contamination was notified by Europe in June 2018. The contaminant was identified as a probable carcinogenic nitrosamine and the recalls of sartan medicines were soon made. Since then, more nitrosamine contaminants in sartan medicines were reported. To broaden the applicability and variety in nitrosamine determination, a multi-analyte method is required. In this study, a feasible and sensitive multi-analyte LC-MS/MS method for determination of 12 nitrosamines in sartans was established, where the active pharmaceutical ingredients and final products merchandised in Taiwan were also examined. Chromatographic separation was achieved on an Xselect® HSS T3 column (15 cm £ 3 mm i.d., 3.5 mm) with gradient elution using mobile phase A consisting of 0.1% formic acid in water and mobile phase B consisting of 0.1% formic acid in acetonitrile/methanol (2:8). Validation of the proposed method was also carried out. The limit of detection and limit of quantification for 12 nitrosamines were 20 ng/g and 50 ng/g, respectively. The intra-day and inter-day recoveries of nitrosamines were among 80e120% with precision of 20% for most nitrosamines within sartans matrices. The method was successfully established and applied to authentic samples which a total of 98 positive samples containing 5 distinct nitrosamines, including N-nitrosodiethylamine, N-nitrosodimethylamine, N-nitroso-N-methyl-4-aminobutyric acid, N-nitrosomorpholine and Nnitrosopiperidine, were detected from 557 authentic samples.
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  • Original Articles
    14 July 2020

    Determination of formaldehyde in cosmetics by HPLC method and acetylacetone method

    P.-W. Wu, C.-C. Chang, S.-S. Chou
    This paper describes an assay method to determine free formaldehyde in cosmetics using High Performance Liquid Chromatography (HPLC), with a pre-column derivation with 2,4-dinitrophenylhydrazine. The derivatives were analyzed using a RP8 column with 45% acetonitrile solution as mobile phase and detected at the wavelength of 345 nm. The detection limit of derived formaldehyde in this HPLC system was 0.2 ppm. Compared with the amounts of formaldehyde analyzed from the 0.2% formaldehyde donors, the results obtained by acetylacetone method were 1.62∼17.35 times higher than that of HPLC method. One hundred cosmetic products purchased during 1995-1996 were investigated. None of those products was labeled formaldehyde. The results showed that 53% of the samples were formaldehyde positive. The amounts of total free formaldehyde were between 3∼165 ppm. All of them were less than 1000 ppm.
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