A Simple Methodology for Preparing Synthetic Multiple-Interaction Chiral Stationary Phase Column for Chiral Drug Analysis

Authors

Gerald K. Shiu

Keywords

Chiral stationary phase, Enantiomers resolution, Column preparation

Abstract

A simple methodology for preparing synthetic multiple-interaction (SMI) chiral stationary phase (CSP) column is described in this report, The column was synthesized by an in situ derivatizing procedure and can be easily prepared with a standard analytical HPLC set-up. The column is a no frills, low cost one, and can be tailored to various packing particle sizes and column lengths. The efficiency of the column is high; over 5,000 plates per 10 cm Applications on resolving some racemic drugs in plasma and formulation are illustrated.

Recommended Citation

Shiu, Gerald K. (1993) "A Simple Methodology for Preparing Synthetic Multiple-Interaction Chiral Stationary Phase Column for Chiral Drug Analysis," Journal of Food and Drug Analysis: Vol. 1 : Iss. 4 , Article 3.
Available at: https://doi.org/10.38212/2224-6614.3070