Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection

Authors

S.M. Richart
Y.-L. Li
Y. Mizushina
Y.-Y. Chang
T.-Y. Chung
G.-H. Chen
J.T.-C. Tzen
K.-S. Shia
W.-L. Hsu

Abstract

Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection. © 2018

Abstract Image

ScienceDirect Link

10.1016/j.jfda.2017.12.006

Recommended Citation

Richart, S.M.; Li, Y.-L.; Mizushina, Y.; Chang, Y.-Y.; Chung, T.-Y.; Chen, G.-H.; Tzen, J.T.-C.; Shia, K.-S.; and Hsu, W.-L. (2018) "Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection," Journal of Food and Drug Analysis: Vol. 26 : Iss. 3 , Article 14.
Available at: https://doi.org/10.1016/j.jfda.2017.12.006

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https://www.sciencedirect.com/science/article/pii/S102194981830022X/pdfft?md5=363fc492b901ffbc4c3183ff8f47be9c&pid=1-s2.0-S102194981830022X-main.pdf