Adverse effects on birth weight of parental illegal drug use during pregnancy and within two years before pregnancy

Ching-Heng Lin, Taichung Veterans General Hospital, Taiwan
Wei-Szu Lin, Taichung Veterans General Hospital, Taiwan
I-An Wang, National Health Research Institutes, Taiwan
Jui Hsu, Division of Research and Analysis, Taiwan Food and Drug Administration, Taiwan
Shiow-Ing Wu, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, TaiwanFollow
Chuan-Yu Chen, enter of Neuropsychiatric Research, National Health Research Institutes, Taiwan

Keywords

Birth weight, Drug criminal record, Duration of drug use, Maternal illegal drug use, Paternal illegal drug use

Abstract

This study investigates possible links between maternal illegal drug use during pregnancy and up to two years before pregnancy with birth weight (BW), and explores the potential role of paternal illegal drug use on low birth weight. A population-based retrospective cohort study was conducted that linked four national databases in Taiwan. A total of 1,698 subjects with a criminal record of schedule I or II illegal drug use within two years before pregnancy were enrolled as the drug-exposed group, and 16,980 matched subjects were enrolled as the unexposed group. Multivariate analysis of BW found a decrease of 108.63 g (95% CI: ¡172.29, ¡44.96), 79.67 g (95% CI: ¡116.91, ¡42.43), and 69.78 g (95% CI: ¡106.71, ¡32.84) in newborns whose mothers used illegal drugs only during pregnancy (period I), only within one year before pregnancy (period II), and only within the second year before pregnancy (period III), respectively. Paternal use of illegal drugs before maternal pregnancy was significantly associated with low birth weight. The paternal effect on low birth weight was opposite the maternal effect. The adverse effect of illegal drug use on birth weight existed even if the mother did not use drugs during pregnancy but had ever used drugs during the two years before pregnancy. Paternal factors' contribution to low birth weight persisted, and the decrement of BW was even greater than the maternal effect within one or two years before pregnancy. Maternal and paternal illegal drug use may have a lasting effect on their offspring's birth weight.

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Recommended Citation

Lin, Ching-Heng; Lin, Wei-Szu; Wang, I-An; Hsu, Jui; Wu, Shiow-Ing; and Chen, Chuan-Yu (2021) "Adverse effects on birth weight of parental illegal drug use during pregnancy and within two years before pregnancy," Journal of Food and Drug Analysis: Vol. 29 : Iss. 2 , Article 12.
Available at: https://doi.org/10.38212/2224-6614.3355