The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry

Yi-Tzu Cho, Department of Cosmetic Applications and Management, Yuh-Ing Junior College of Health Care & Management, No. 15, Ln. 420, Dachang 2nd Rd. Sanmin Dist., Kaohsiung 807634, TaiwanFollow
Hung Su, Department of Chemistry, National Sun Yat-Sen University, No. 70, Lienhai Rd., Gushan Dist., Kaohsiung 804201, Taiwan
Ching-Ying Wu, Department of Dermatology, College of Medicine, Kaohsiung Medical University 807378, Kaohsiung, Taiwan
Jingyueh Jeng, Department of Medicinal Chemistry, Chia Nan University of Pharmacy and Science, Tainan 717301, Taiwan
Chi-Wei Lee, Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Deng‐Chyang Wu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
Tiao-Lai Huang, Department of Psychiatry, Chang Gung Memorial Hospital–Kaohsiung Medical Center and Chang Gung University College of Medicine, No. 123, Ta-pei Rd., Niaosung District, Kaohsiung 833401, Taiwan
Jentaie Shiea, Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

Keywords

skin, epidermis, terbinafine, thermal desorption-electrospray ionization tandem mass spectrometry

Abstract

We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) to characterize trace terbinafine, which was secreted on patient’s skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.

Abstract Image

Recommended Citation

Cho, Yi-Tzu; Su, Hung; Wu, Ching-Ying; Jeng, Jingyueh; Lee, Chi-Wei; Wu, Deng‐Chyang; Huang, Tiao-Lai; and Shiea, Jentaie (2022) "The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry," Journal of Food and Drug Analysis: Vol. 30 : Iss. 2 , Article 10.
Available at: https://doi.org/10.38212/2224-6614.3413