BMP4 complex

Chi-Chou Huang, Department of Colorectal Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
Chia-Hung Hung, Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yi-Ju Lee, Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Tsui-Hwa Tseng, Department of Medical Chemistry, Chung Shan Medical University, Taichung, Taiwan.
Yean-Jang Lee, Department of Chemistry, National Changhua University of Education, Changhua, Taiwan.
Shao-Hsuan Kao, Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.Follow
Chau-Jong Wang, Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.Follow

Keywords

Bone morphogenetic protein 4; Camphorataimide-B; Colorectal cancer; FAK; Snail

Abstract

Camphorataimide B (CamB) has anticancer activities against several tumors. Here, we aimed to investigate the mechanism(s) by which CamB inhibits metastasis of colorectal cancer (CRC) cells. Low-dose CamB did not affect the cell viability and cell cycle progression of CRC cells, but significantly inhibited the metastatic potentials of CRC cells. Mechanically, CamB reduced the protein and mRNA expression of BMP4, and inhibited Smad and FAK/Src/Akt signaling. CamB also decreased Snail levels by promoting its degradation via proteasome and thereafter reduced Snail-mediated BMP4 transcription. Moreover, CamB considerably inhibited the in vivo metastasis of DLD-1 cells in xenograft mice.

Abstract Image

Recommended Citation

Huang, Chi-Chou; Hung, Chia-Hung; Lee, Yi-Ju; Tseng, Tsui-Hwa; Lee, Yean-Jang; Kao, Shao-Hsuan; and Wang, Chau-Jong (2022) "Camphorataimide B suppresses the metastasis of human colorectal cancer cell by inhibiting Smad/FAK/Akt axis and promoting degradation of Snail/BMP4 complex," Journal of Food and Drug Analysis: Vol. 30 : Iss. 2 , Article 7.
Available at: https://doi.org/10.38212/2224-6614.3405