Polyvinylpyrrolidone-passivated fluorescent Iron oxide quantum dots for turn-off detection of tetracycline in biological fluids

Sri Sudewi, Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, R.O.C.
Lutfi Chabib, Pharmacy Study Program, Faculty of Mathematics and Science, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia
Muhammad Zulfajri, Department of Chemistry Education, Universitas Serambi Mekkah, Banda Aceh, Aceh 23245, Indonesia
Gangaraju Gedda, Department of Chemistry, School of Engineering, Presidency University, Bangalore,560064, Karnataka, India
Genin Gary Huang, Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, R.O.C.Follow

Keywords

Fluorescence sensor, Iron oxide quantum dots, Tetracycline, Turn-off

Abstract

Tetracycline is an antibiotic that has been prescribed for COVID-19 treatment, raising concerns about antibiotic resistance after long-term use. This study reported fluorescent polyvinylpyrrolidone-passivated iron oxide quantum dots (IO QDs) for detecting tetracycline in biological fluids for the first time. The as-prepared IO QDs have an average size of 2.84 nm and exist a good stability under different conditions. The IO QDs’ tetracycline detection performance could be attributed to a combination of static quenching and inner filter effect. The IO QDs displayed high sensitivity and selectivity toward tetracycline and achieved a good linear relationship with the corresponding detection limit being 91.6 nM.

Abstract Image

Recommended Citation

Sudewi, Sri; Chabib, Lutfi; Zulfajri, Muhammad; Gedda, Gangaraju; and Huang, Genin Gary (2023) "Polyvinylpyrrolidone-passivated fluorescent Iron oxide quantum dots for turn-off detection of tetracycline in biological fluids," Journal of Food and Drug Analysis: Vol. 31 : Iss. 1 , Article 12.
Available at: https://doi.org/10.38212/2224-6614.3440