Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation

Chun-Yu Lin, Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Yi-Ju Chen, Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Chih-Hsuan Hsu, Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Yu-Hsuan Lin, Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Peng-Tzu Chen, Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Ting-Han Kuo, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Chris T. Ho, Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Hsin-Hua Chen, Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Sih-Jia Huang, Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Ho-Chieh Chiu, Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Taiwan, R.O.C.
Chin-Chu Chen, Biotech Research Institute, Grape King Bio, Taiwan, R.O.C.
Eric Hwang, Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan, R.O.C.Follow

Keywords

Axotomy, Bioactive, Erinacines, Neurodegenerative disease, Neurotrophic factor

Abstract

Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.

Abstract Image

Recommended Citation

Lin, Chun-Yu; Chen, Yi-Ju; Hsu, Chih-Hsuan; Lin, Yu-Hsuan; Chen, Peng-Tzu; Kuo, Ting-Han; Ho, Chris T.; Chen, Hsin-Hua; Huang, Sih-Jia; Chiu, Ho-Chieh; Chen, Chin-Chu; and Hwang, Eric (2023) "Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation," Journal of Food and Drug Analysis: Vol. 31 : Iss. 1 , Article 3.
Available at: https://doi.org/10.38212/2224-6614.3446