Determination of 24 sulfonamide antibiotics in instant pastries by modified QuEChERS coupled with ultra performance liquid chromatography-tandem mass spectrometry

Shuo Li, Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, China
Can Zhang, School of Public Health, Hebei Medical University, Shijiazhuang, China
Hui-Xin Tang, Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, China
Yue Gu, Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, China
Ai-Jing Guo, Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, China
Ke Wang, Shijiazhuang Technology Innovation Center for Chemical Poison Detection and Risk Early Warning, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, ChinaFollow
Kao-Qi Lian, School of Public Health, Hebei Medical University, Shijiazhuang, China

Keywords

Instant pastries; QuEChERS; Sulfonamide antibiotics; Ultra performance liquid chromatography-tandem mass spectrometry

Abstract

There were few reports about antibiotic residues in egg-containing products. In the study, an effective method for the simultaneous determination of 24 sulfonamide antibiotics in two instant pastries based on a modified QuEChERS sample preparation technique coupled with ultra performance liquid chromatography-tandem mass spectrometry was developed. The results show that the average recoveries of the SAs at 5, 10, and 50 µg·kg^-1 levels were 67.6%-103.8%, with relative standard deviations (RSD) of 0.80-9.23%. The limit of detections (LODs) and limit of quantitations (LOQs) were 0.01-0.14 µg∙kg^-1 and 0.02-0.45 µg∙kg^-1, respectively. This method was suitable for analysis of 24 SAs in instant pastries.

Abstract Image

Recommended Citation

Li, Shuo; Zhang, Can; Tang, Hui-Xin; Gu, Yue; Guo, Ai-Jing; Wang, Ke; and Lian, Kao-Qi (2023) "Determination of 24 sulfonamide antibiotics in instant pastries by modified QuEChERS coupled with ultra performance liquid chromatography-tandem mass spectrometry," Journal of Food and Drug Analysis: Vol. 31 : Iss. 1 , Article 5.
Available at: https://doi.org/10.38212/2224-6614.3434