Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana

Ching-Yi Lu, School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan, R.O.C.
Zheng-Ying Huang, School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan, R.O.C.
Meng-Chin Chen, School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan, R.O.C.
Hui-Kang Liu, National Research Institute of Chinese Medicine, Taipei 11221, Taiwan, R.O.C.
Shoei-Sheng Lee, School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan, R.O.C.
Chia-Chuan Chang, School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan, R.O.C.Follow

Keywords

α-glucosidase inhibitor, Boehmeria formosana, GLP- 1-enhancing ability, Phenanthroindolizidine alkaloids, Secondary metabolites

Abstract

Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5- and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures.

Abstract Image

Recommended Citation

Lu, Ching-Yi; Huang, Zheng-Ying; Chen, Meng-Chin; Liu, Hui-Kang; Lee, Shoei-Sheng; and Chang, Chia-Chuan (2023) "Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana," Journal of Food and Drug Analysis: Vol. 31 : Iss. 4 , Article 12.
Available at: https://doi.org/10.38212/2224-6614.3483