Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects

Authors

Chen-Che Hsieh, Institute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan. R.O.C.
Chih-Yao Hou, Department of Seafood Science, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan. R.O.C.
Hsiao-Yun Lei, Institute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan. R.O.C.
Darin Khumsupan, Institute of Biotechnology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan. R.O.C.
Huey-Jine Chai, Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung 20246, Taiwan. R.O.C.
Pek-Kui Lim, School of Food Studies and Gastronomy, Taylor's University, Subang Jaya, Selangor 47500, Malaysia.
Cheng-Chih Hsu, Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan. R.O.C.
Sz-Jie Wu, Department of Horticulture and Landscape Architecture, National Taiwan University, Taipei, Taiwan. R.O.C.
Kai-Wen Cheng, Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan. R.O.C.
Yi-Chen Chen, Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan. R.O.C.
Kuan-Chen Cheng, Institute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan. R.O.C.Follow

Keywords

Anti-melanogenesis, Depigmentation, Ganoderma formosanum, Synergistic effects, Tyrosinase inhibition

Abstract

This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol. The enhanced binding of identified compounds to tyrosinase facilitated synergistic inhibitory effects on melanin production. This study highlights the potential of GFE-EA as a source of natural tyrosinase inhibitors and contributes to understanding the role of active compounds extracted from G. formosanum.

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Recommended Citation

Hsieh, Chen-Che; Hou, Chih-Yao; Lei, Hsiao-Yun; Khumsupan, Darin; Chai, Huey-Jine; Lim, Pek-Kui; Hsu, Cheng-Chih; Wu, Sz-Jie; Cheng, Kai-Wen; Chen, Yi-Chen; and Cheng, Kuan-Chen (2024) "Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects," Journal of Food and Drug Analysis: Vol. 32 : Iss. 4 , Article 11.
Available at: https://doi.org/10.38212/2224-6614.3509

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