Protective role of Hsian-tsao ethanol extract against body fat, serum lipid profiles, and hepatic lipid profiles in high-fat diet-fed rats

Authors

Ching-Chang Cho, Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
Gow-Chin Yen, Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
Hsin-Yi Lee, Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
Chun-Tse Tsai, Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
Wei-Tang Chang, Department of Nutrition and Health Sciences, Chinese Culture University, Taipei, Taiwan
Chin-Lin Hsu, Department of Nutrition, Chung Shan Medical University, Taichung, TaiwanFollow

Keywords

Anti-obesity, Ethanol extract of Hisan-tsao, High-fat diet, Mesona procumbens Hemsl., Oxidative stress

Abstract

This study investigated the preventive effects of a 40% ethanol extract of Hsian-tsao (40EEHT) on obesity in high-fat diet (HFD)-induced obese rats. Male Wistar rats were administered 0, 100, 200, or 500 mg/kg of 40EEHT, resulting in reduced body weight, total body fat, and hepatic tissue weight after 8 weeks. 40EEHT also decreased adipocyte size, improved lipid profiles, alleviated oxidative stress, and enhanced hepatic antioxidant enzyme activities. Additionally, it regulated fatty acid metabolism by reducing lipogenesis and increasing lipolysis and β-oxidation, suggesting its potential as an anti-obesity dietary supplement.

Abstract Image

Recommended Citation

Cho, Ching-Chang; Yen, Gow-Chin; Lee, Hsin-Yi; Tsai, Chun-Tse; Chang, Wei-Tang; and Hsu, Chin-Lin (2025) "Protective role of Hsian-tsao ethanol extract against body fat, serum lipid profiles, and hepatic lipid profiles in high-fat diet-fed rats," Journal of Food and Drug Analysis: Vol. 33 : Iss. 1 , Article 5.
Available at: https://doi.org/10.38212/2224-6614.3527

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