Keywords
Bacillus coagulans-198 (BC198), 5-fluorouracil (5-FU), Intestinal inflammation, Microbiota, Mucositis
Abstract
5-Fluorouracil (5-FU) disrupts intestinal cells and causes dysbiosis in the gut microbiota. This study explores the potential of Bacillus coagulans-198 (BC198) to mitigate gut microbiota imbalance and mucositis caused by 5-fluorouracil. L-glutamine is used to alleviate mucositis, and this study found that BC198 exhibits protective effects on the gut, including maintaining a healthy microbiota and reducing intestinal inflammation, regardless of whether L-glutamine is used in combination. Therefore, it can help reduce the deterioration of the gut environment caused by 5-fluorouracil. BC198 can be provided to cancer patients to prevent severe side effects, thereby improving their treatment outcomes and nutritional status.
Recommended Citation
Chen, Wei-Jen; Shen, Siou-Ru; Hsu, Wei-Hsuan; Lee, Bao-Hong; Wei, Yu-Shan; Chu, Hui-Fang; Tseng, Ming-Chung; and Shen, Tang-Long
(2025)
"Bacillus coagulans 198 and L-glutamine in combination attenuated intestinal mucositis in a 5-FU-induced BALB/c mouse model via modulation of gut microbial community structure and diversity,"
Journal of Food and Drug Analysis: Vol. 33
:
Iss.
1
, Article 6.
Available at: https://doi.org/10.38212/2224-6614.3535
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